HRID348053

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID69335

1,4-Bis(bromomethyl)benzene

C8H8Br2

结构：COc1ccc(C2C(CCC(O)c3ccc(O)cc3)C(=O)N2c2ccc(F)cc2)cc1

HCID21083177

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2C(CCC(O)c3ccc(OCc4ccc(CBr)cc4)cc3)C(=O)N2c2ccc(F)cc2)cc1

HCID21083178

未命名化合物

PROCEDURE

实验过程

1-(4-Fluorophenyl)-3-[3-hydroxy-3-(4-hydroxyphenyl)-propyl]-4-(4-methoxyphenyl)-azetidin-2-one was reacted with 1,4-bisbromomethylbenzene and potassium carbonate analogously to Example IV, giving a colorless solid (29) of molecular weight 604.52 (C33H31BrFNO4); MS (ESI): 605.2 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1a88ee0aec444c48a1c1122a18fb2893
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07176194B2
来源说明: uspto-grants-2007_02

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:11]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[CH:10]([CH2:20][CH2:21][CH:22]([OH:30])[C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)[C:9]2=[O:31])=[CH:4][CH:3]=1.[Br:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40]Br)=[CH:36][CH:35]=1.C(=O)([O-])[O-].[K+].[K+]>>[Br:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40][O:29][C:26]2[CH:25]=[CH:24][C:23]([CH:22]([OH:30])[CH2:21][CH2:20][CH:10]3[CH:11]([C:12]4[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=4)[N:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)[C:9]3=[O:31])=[CH:28][CH:27]=2)=[CH:36][CH:35]=1