tert-Butanol → HCID 69523188, compound

HRID 348455Notes

Reaction equation

HRID 348455 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[C:22](O)([CH3:25])([CH3:24])[CH3:23].C(OCC)(=O)C>CCCCCC>[C:22]([O:20][C:19](=[O:21])[CH2:18][O:17][C:14]1[N:13]=[CH:12][C:11]([C:9](=[O:10])[NH:8][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[CH:16][N:15]=1)([CH3:25])([CH3:24])[CH3:23]

Participants

5

Reactant 3

HCID 6386tert-ButanolHCID 8857Ethyl AcetateHCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

Product 1

HCID 69523188HCID 69523188, compoundYield 8%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using tert-butyl alcohol (9.6 mg, 0.13 mmol) as the source alcohol. Chromatography (1:1 ethyl acetate:hexane) through SiO2 yielded 5 mg (8%) of the titled compound. ESI-MS m/z 348 (MH+), 346 (M−H−).

Sources & evidence

ORD record
ord-cec8160f24474e86ba22ffdf07cf233b
Source dataset
uspto-grants-2007_02
Patent number
US07176310B1

Reaction notes

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