反应详情

Lithium aluminum hydride (5.21 g) was suspended in THF (243 ml). Then, a solution of the compound (24.3 g) obtained in Example 103-1 in THF (243 ml) was gradually added to the suspension over 50 minutes while stirring under ice-cooling, followed by stirring at room temperature for 1 hour. The reaction solution was added with sodium sulfate decahydrate and a 20% sodium hydroxide aqueous solution and then filtrated through Celite. The filtrate was concentrated under reduced pressure and dried under vacuum, thereby obtaining the subject compound (18.5 g).

1. temperaturecooling
2. stirringby stirring at room temperature for 1 hour
3. filtrationa 20% sodium hydroxide aqueous solution and then filtrated through Celite
4. concentrationThe filtrate was concentrated under reduced pressure
5. customdried under vacuum