反应详情

The compound (189.7 mg) obtained in Example 127-10 was dissolved in DMF (5.69 ml) and added with potassium carbonate (108.5 mg) and carbethoxyphthalimide (172.0 mg), followed by stirring at room temperature for 3 hours. The reaction solution was added with water. Then, the solution was subjected to separation/extraction with chloroform, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (253.9 mg) as a yellow oily substance.

1. extractionThen, the solution was subjected to separation/extraction with chloroform
2. dry with materialdried with anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified through silica gel column chromatography (chloroform/methanol)