反应详情

Sodium hydride (60% dispersion in mineral oil) (0.58 g) was added portionwise to a solution of 4-oxothiazolidine (1.50 g) and 4-methoxybenzenesulfonyl chloride (3.01 g) in tetrahydrofuran (30 ml) at 0° C. with stirring and the mixture was stirred for 1 hour at the same temperature. After the solvent was evaporated in vacuo, the residue was mixed with ethyl acetate (10 ml) and water (50 ml) and the resultant precipitate was collected by filtration. The cake was washed with water and diisopropyl ether and recrystallized from a mixture of ethanol and ethyl acetate to give 3-(4-methoxybenzenesulfonyl)-4-oxothiazolidine (1.65 g) as slightly brown prisms.

1. stirringthe mixture was stirred for 1 hour at the same temperature
2. customAfter the solvent was evaporated in vacuo
3. additionthe residue was mixed with ethyl acetate (10 ml) and water (50 ml)
4. filtrationthe resultant precipitate was collected by filtration
5. washThe cake was washed with water and diisopropyl ether
6. customrecrystallized from a mixture of ethanol and ethyl acetate