Trifluoroacetic acid → HCID 13800254, compound

HRID 34937Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][CH2:11][CH2:12][NH:13]C(=O)OC(C)(C)C)=[O:9])[CH:3]=1.FC(F)(F)C(O)=O>>[ClH:1].[NH2:13][CH2:12][CH2:11][NH:10][C:8]([C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=1)=[O:9]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 13800223HCID 13800223, compound2×

Product 1

HCID 13800254HCID 13800254, compound

Procedure

10.6 g of t-butyl [2-(4-chloropyridine-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 3, paragraph 2. The residue was converted into the hydrochloride which was recrystallized from methanol/ether, whereby there was obtained N-(2-aminoethyl)-4-chloropyridine-2-carboxamide hydrochloride as beige crystals, m.p. 228°-229°.

Workup

customwas recrystallized from methanol/ether

Sources & evidence

ORD record: ord-aa4a6fdce962486ebfdad34d01f1a243
Source dataset: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04764522

Reaction notes

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