反应详情

A mixture of 1.87 g of 3,4-diaminothiophene dihydrochloride, 60 ml of anhydrous tetrahydrofuran (THF) and 2.58 g of N-ethyl-N,N-diisopropylamine was stirred at room temperature for 30 minutes and then admixed with 1.5 g of 4-methyl-3-thienyl isothiocyanate. After stirring over approx. 18 hours, the solvent was distilled off, the residue admixed with water and extracted repeatedly with ethyl acetate. After the combined organic phases had been treated with activated carbon, they were dried over sodium sulfate and the solvent was once again distilled off. The N-(3-amino-4-thienyl)-N′-(4-methyl-3-thienyl)thiourea was obtained as an amorphous foamy solid.

1. stirringAfter stirring over approx. 18 hours
2. distillationthe solvent was distilled off
3. extractionthe residue admixed with water and extracted repeatedly with ethyl acetate
4. additionAfter the combined organic phases had been treated with activated carbon, they
5. dry with materialwere dried over sodium sulfate
6. distillationthe solvent was once again distilled off