Acetic Anhydride → methyl 3-acetamidothiophene-2-carboxylate

HRID 349427Notes

Reaction equation

HRID 349427 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([O:9][CH3:10])=[O:8].[C:11](OC(=O)C)(=[O:13])[CH3:12]>C1(C)C=CC=CC=1>[C:11]([NH:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([O:9][CH3:10])=[O:8])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

Product 1

HCID 729216methyl 3-acetamidothiophene-2-carboxylate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

was obtained by reacting 471 g of methyl 3-aminothiophene-2-carboxylate with 226.64 ml of acetic anhydride in 500 ml of toluene. Colorless crystalline product. M.p. 94–95° C.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-20c23600c5dc4855babc10221f36ebf8
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Reaction notes

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