反应详情

A solution of 25.0 g of pyrazinecarboxylic acid in 300 ml of methylene chloride and 20.1 ml of ethyl chloroformate was treated dropwise at 0° within 1/2 hour with 31 ml of triethylamine. After 1/2 hour the solution obtained was added dropwise at 0° to 68 ml of ethylenediamine in 200 ml of methylene chloride and the mixture was left to stir further for 1 hour without external cooling. Thereafter, the precipitated material was filtered off and the filtrate was evaporated to dryness on a rotary evaporator under reduced pressure. The residue was recrystallized twice from isopropanol, whereby there was obtained N-(2-aminoethyl)pyrazine-2-carboxamide hydrochloride, m.p. 205°-207°.

1. customAfter 1/2 hour the solution obtained
2. waitthe mixture was left
3. filtrationThereafter, the precipitated material was filtered off
4. customthe filtrate was evaporated to dryness on a rotary evaporator under reduced pressure
5. customThe residue was recrystallized twice from isopropanol