Hydrochloric Acid → 4-Aminomethyl-1-propyl-5-aminopyrazole dihydrochloride

HRID 349546Notes

Reaction equation

HRID 349546 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][N:6]([CH2:28][CH2:29][CH3:30])[C:7]=1[NH:8]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:31]>C(OCC)(=O)C.CO>[ClH:31].[ClH:31].[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][N:6]([CH2:28][CH2:29][CH3:30])[C:7]=1[NH2:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 179619914-Aminomethyl-1-propyl-5-tritylaminopyrazole

Product 1

HCID 179620074-Aminomethyl-1-propyl-5-aminopyrazole dihydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 4-aminomethyl-1-propyl-5-tritylaminopyrazole (9.6 g) in a mixture of ethyl acetate (150 ml) and methanol (30 ml) was added 4N hydrochloric acid in ethyl acetate (24.2 ml), and the mixture was stirred at room temperature for 2 hours. The resulting precipitate was collected by filtration and dried in vacuo to give 4-aminomethyl-1-propyl-5-aminopyrazole dihydrochloride (3.3 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customdried in vacuo

Sources & evidence

ORD record
ord-48cce846ece7415caa44208aa6bb34a2
Source dataset
uspto-grants-2007_02
Patent number
US07179801B2

Reaction notes

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