反应详情

温度

65 °C

To a suspension of lithium aluminum hydride (2.7 g) in tetrahydrofuran (150 ml) was added 4-triphenylmethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (8.5 g) under ice-cooling. The mixture was stirred at 65° C. for 16 hours. After cooling on an ice bath, potassium fluoride (16.5 g) and water (5 ml) were added to the reaction mixture. The insoluble materials were removed by filtration. The filtrate was concentrated in vacuo to give 1-(4-triphenylmethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)methylamine (8.4 g) as a solid.

1. temperaturecooling
2. temperatureAfter cooling on an ice bath
3. customThe insoluble materials were removed by filtration
4. concentrationThe filtrate was concentrated in vacuo