反应详情

To a mixture of 3-(4-formyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)propionic acid (18.0 g), triethylamine (9.8 g) and tetrahyrofuran (300 ml) was added dropwise ethyl chloroformate (9.6 g) under ice-cooling. The mixture was stirred under ice-cooling for 30 minutes. To the reaction mixture was added a solution of sodium azide (6.68 g) in water (100 ml), and the mixture was stirred at room temperature for 30 minutes. To the reaction mixture was added methylene chloride, and the aqueous layer was separated. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. To the oily residue was added methanol (100 ml), and the mixture was stirred under reflux for 1.5 hours. The reaction mixture was concentrated in vacuo to give crude methyl N-[2-(4-formyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)ethyl]carbamate as an oil. This product was used in the next step without further purification.

1. temperaturecooling
2. temperaturecooling for 30 minutes
3. stirringthe mixture was stirred at room temperature for 30 minutes
4. customthe aqueous layer was separated
5. washThe organic layer was washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo
9. additionTo the oily residue was added methanol (100 ml)
10. stirringthe mixture was stirred
11. temperatureunder reflux for 1.5 hours
12. concentrationThe reaction mixture was concentrated in vacuo