Hydrochloric Acid → (1-Chloropropyl)benzene

HRID 34963Notes

Reaction equation

HRID 34963 reaction equation
[C:1]1([CH:7](O)[CH2:8][CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:11]>O>[Cl:11][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71471-Phenyl-1-propanol

Product 1

HCID 524241(1-Chloropropyl)benzene

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

13.6 g (0.1 mole) of 1-phenylpropan-1-ol are taken up in petroleum ether and are reacted at -20° C. with hydrochloric acid until the precipitation of water is terminated. Subsequently, the organic phase is washed neutral with water, dried (sodium sulfate) and the petroleum ether removed in a vacuum. The bright yellow, thermolabile oil is used without further purification. The oil has an Rf of 0.8 (CH2Cl2) and is attained in a yield of 13.1 g (85%).

Workup

  1. customis terminated
  2. washSubsequently, the organic phase is washed neutral with water
  3. dry with materialdried (sodium sulfate)
  4. customthe petroleum ether removed in a vacuum
  5. customThe bright yellow, thermolabile oil is used without further purification

Sources & evidence

ORD record
ord-dcd316a38b4f4ea7a34c064d42946357
Source dataset
uspto-grants-1988_08
Patent number
US04764533

Reaction notes

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