反应详情

To 2-chloromethyloxirane (95 g, 1.03 mole) was added a mixture of water (3.08 g, 0.17 mole) and diethylamine (106.2 mL, 1.03 mole) at 30° C. The reaction mixture was then stirred at 28–35° C. for 6 hour and cooled to 20–25° C. to give 1-chloro-3-diethylamino-propan-2-ol.

1. temperaturecooled to 20–25° C.