反应详情

Lithium aluminium hydride (300 mg) was added gradually to a solution of ethyl 1-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridylmethyl]-3-phenyl-1H-pyrazole-4-carboxylate (1.56 g) in tetrahydrofuran (70 ml) at 0° C., which was stirred for 2 hours. Sodium sulfate-decahydrate (3.40 g) was added to the reaction mixture, and the precipitate was filtered. The filtrate was concentrated, and residue was subjected to silica gel column chromatography to obtain 1-(6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridylmethyl]-3-phenyl-1H-pyrazol-4-ylmethanol (1.27 g, yield 89%) as a colorless oily substance from the fraction eluted with acetone-hexane (2:3, volume ratio).

1. filtrationthe precipitate was filtered
2. concentrationThe filtrate was concentrated