反应详情

Sodium borohydride (0.45 g) was added to a mixture of 4-(2-phenyl-4-thiazolylmethoxy)benzaldehyde (6.35 g), tetrahydrofuran (30 ml) and methanol (20 ml) under ice-cooling, which was stirred at room temperature for 30 minutes. The reaction mixture was neutralized with dilute hydrochloric acid and water to give a precipitate, which was collected by filtration and then air-dried to obtain crystals of 4-(2-phenyl-4-thiazolylmethoxy)benzyl alcohol (5.76 g, yield 90%). This was recrystallized from ethyl acetate-hexane to obtain colorless needles. Melting point: 145–146° C.

1. temperaturecooling
2. customto give a precipitate, which
3. filtrationwas collected by filtration
4. customair-dried