HRID350020

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Na+].[Na+]

HCID62649

Disodium sulfate decahydrate

H20Na2O14S

HCID21226445

未命名化合物

结构：CCOC(=O)c1cn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)nc1-c1cccs1

HCID23024863

未命名化合物

PRODUCTS

生成物

结构：Cc1oc(-c2ccccc2)nc1COc1ccc(Cn2cc(CO)c(-c3cccs3)n2)cc1

HCID69424441

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Lithium aluminium hydride (1100 mg) was added gradually to a solution of ethyl 1-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl]-3-(2-thienyl)-1H-pyrazole-4-carboxylate (14.39 g) in tetrahydrofuran (50 ml) at 0° C., which was stirred for 30 minutes. Sodium sulfate decahydrate (12.14 g) was added to the reaction mixture, and the precipitate was removed by filtration. The filtrate was concentrated, and the residue was subjected to silica gel column chromatography to obtain [1-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl]-3-(2-thienyl)-1H-pyrazol-4-yl]methanol (12.20 g, yield: 93%) as pale yellow oily substance from the fraction eluted with ethyl acetate-hexane (1:1, volume ratio).

WORKUP

后处理

customthe precipitate was removed by filtration
concentrationThe filtrate was concentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ecdf41d8dd7b4daf8acadf5b85d25002
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07179823B1
来源说明: uspto-grants-2007_02

反应 SMILES

[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]1[O:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:10][C:9]=1[CH2:19][O:20][C:21]1[CH:42]=[CH:41][C:24]([CH2:25][N:26]2[CH:30]=[C:29]([C:31](OCC)=[O:32])[C:28]([C:36]3[S:37][CH:38]=[CH:39][CH:40]=3)=[N:27]2)=[CH:23][CH:22]=1.O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH3:7][C:8]1[O:12][C:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[N:10][C:9]=1[CH2:19][O:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:25][N:26]2[CH:30]=[C:29]([CH2:31][OH:32])[C:28]([C:36]3[S:37][CH:38]=[CH:39][CH:40]=3)=[N:27]2)=[CH:41][CH:42]=1