反应详情

2-[3-[3-Formylphenoxy]propyl]-1H-isoindole-1,3-dione (50 g) and piperidine (20.7 g) in ethyl acetate (750 ml) were hydrogenated over 10% palladium/carbon catalyst. The catalyst was removed by filtration and the solvent evaporated and hydrazine hydrate (40 ml) was added to an ethanolic solution of the residue at 25°. After 67 hr the reaction mixture was diluted with ether, filtered and the filtrate was distilled to give the title compound as a colourless oil (31.05 g) b.p. 154°-8°/0.15 mm. TLC silica, methanol/0.88 ammonia 80:1, Rf 0.2.

1. customThe catalyst was removed by filtration
2. customthe solvent evaporated
3. additionhydrazine hydrate (40 ml) was added to an ethanolic solution of the residue at 25°
4. additionAfter 67 hr the reaction mixture was diluted with ether
5. filtrationfiltered
6. distillationthe filtrate was distilled