Dichloromethane → HCID 21957076, compound

HRID 350690Notes

Reaction equation

HRID 350690 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[CH:12][CH:11]=1)(C)(C)C.ClCCl>FC(F)(F)C(O)=O>[N:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:13]1[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][NH2:7])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 21027861HCID 21027861, compound

Product 1

HCID 21957076HCID 21957076, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

[2-(4-Pyridin-2-yl-phenyl)-ethyl]-carbamic acid tert-butyl ester was dissolved in a 1:1 mixture of trifluroacetic acid:dichloromethane. The reaction mixture was stirred at room temperature overnight after which the product was recovered upon solvent removal. The TFA salt was used in the next step without further purification.

Workup

  1. customwas recovered upon solvent removal
  2. customThe TFA salt was used in the next step without further purification

Sources & evidence

ORD record
ord-958ab82382b44ea9b426709fd53303a6
Source dataset
uspto-grants-2007_02
Patent number
US07183281B2

Reaction notes

Loading…