Hydrochloric Acid → HCID 22609743, compound

HRID 350715Notes

Reaction equation

HRID 350715 reaction equation
[CH3:1][N:2]([CH2:10][CH2:11][S:12]([CH3:15])(=[O:14])=[O:13])C(=O)OC(C)(C)C.[ClH:16]>C(OCC)(=O)C>[ClH:16].[CH3:1][NH:2][CH2:10][CH2:11][S:12]([CH3:15])(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23061773HCID 23061773, compound

Product 1

HCID 22609743HCID 22609743, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a mixture of tert-butyl N-methyl-N-[2-(methylsulfonyl)ethyl]carbamate (0.81 g) and ethyl acetate (10 mL) was added dropwise a 4N hydrochloric acid.ethyl acetate solution (2 mL) with stirring under ice-cooling. After stirring at room temperature overnight, the precipitated crystals were collected by filtration and washed with ethyl acetate to give N-methyl-N-[2-(methylsulfonyl)ethyl]amine hydrochloride as crystals (0.38 g, yield 64%). Recrystallization from ethanol gave colorless prism crystals. melting point: 259–260° C.

Workup

  1. temperaturecooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-9b9f410b6099458f9cb69ec6dc0cd8c9
Source dataset
uspto-grants-2007_02
Patent number
US07183276B2

Reaction notes

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