Hydrochloric Acid → 4-({3-[4-(4-Chlorophenyl)-2-phenyl-5-oxazolyl]propanoyl}amino)benzoic acid

HRID 350746Notes

Reaction equation

HRID 350746 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[O:11][C:12]=2[CH2:13][CH2:14][C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([O:26]CC)=[O:25])=[CH:20][CH:19]=2)=[O:16])=[CH:4][CH:3]=1.[OH-].[K+].C(O)C.Cl>O.O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[O:11][C:12]=2[CH2:13][CH2:14][C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([OH:26])=[O:25])=[CH:20][CH:19]=2)=[O:16])=[CH:6][CH:7]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 21088665HCID 21088665, compound

Product 1

HCID 210887274-({3-[4-(4-Chlorophenyl)-2-phenyl-5-oxazolyl]propanoyl}amino)benzoic acid

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 3-[4-(4-chlorophenyl)-2-phenyl-5-oxazolyl]-N-[4-(ethoxycarbonyl)phenyl]propionamide (0.70 g), potassium hydroxide (0.26 g), ethanol (20 ml) and tetrahydrofuran (10 ml) was stirred at room temperature for 5 hrs and further stirred at 50° C. for 3 hrs. The reaction mixture was poured into water and acidified with 1N hydrochloric acid. The mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then with saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give a colorless powder. Recrystallization from chloroform-ethanol gave 4-({3-[4-(4-chlorophenyl)-2-phenyl-5-oxazolyl]propanoyl}amino)benzoic acid as colorless prism crystals (0.51 g, 75%). melting point: 243–244° C.

Workup

  1. stirringfurther stirred at 50° C. for 3 hrs
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe ethyl acetate layer was washed with water
  4. dry with materialwith saturated brine, dried over anhydrous magnesium sulfate
  5. concentrationconcentrated
  6. customto give a colorless powder
  7. customRecrystallization from chloroform-ethanol

Sources & evidence

ORD record
ord-f880dcc49842413db92d9b7faf56150b
Source dataset
uspto-grants-2007_02
Patent number
US07183276B2

Reaction notes

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