反应详情

温度

50 °C

To methyl 2-chloro-4-methylbenzoate (1.00 g, 5.42 mmol) in THF (10 mL) MeOH (5 mL) and H2O (2.5 mL) is added 2N LiOH (8.12 mL, 16.2 mmol). The reaction mixture is heated at 50° C. for 2.5 hr, cooled to room temperature, then quenched with 5N HCl (3.24 mL). The mixture is concentrated to remove the TBF and MeOH. A white precipitate is formed and is filtered. After drying, 0.922 g (100%) of 2-chloro-4-methylbenzoic acid is isolated. ESIMS m/e 169 (M−−1; 35Cl) and 171 (M−−1; 37Cl).

1. temperaturecooled to room temperature
2. customquenched with 5N HCl (3.24 mL)
3. concentrationThe mixture is concentrated
4. customto remove the TBF and MeOH
5. customA white precipitate is formed
6. filtrationis filtered
7. customAfter drying