Triphenylphosphine → HCID 21091171, compound

HRID 351193Notes

Reaction equation

HRID 351193 reaction equation
CCOC(/N=N/C(OCC)=O)=O.[CH:13]([C:16]1[CH:20]=[C:19]([C:21]2[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=2)[N:18]([C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[N:17]=1)([CH3:15])[CH3:14].[C:36]([O:40][C:41]([NH:43][CH2:44][CH2:45]O)=[O:42])([CH3:39])([CH3:38])[CH3:37].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[CH:13]([C:16]1[CH:20]=[C:19]([C:21]2[CH:22]=[CH:23][C:24]([O:27][CH2:45][CH2:44][NH:43][C:41](=[O:42])[O:40][C:36]([CH3:39])([CH3:38])[CH3:37])=[CH:25][CH:26]=2)[N:18]([C:28]2[CH:29]=[CH:30][C:31]([O:34][CH3:35])=[CH:32][CH:33]=2)[N:17]=1)([CH3:15])[CH3:14]

Participants

6

Reactant 4

HCID 11776Triphenylphosphine2×HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 5462977Diethyl azodicarboxylate2×HCID 135737385HCID 135737385, compound

Product 1

HCID 21091171HCID 21091171, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Diethylazodicarboxylate (259 mg) was added to a mixture of 4-[3-isopropyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]phenol obtained by Example 1-3 (305 mg), 2-t-butoxycarbonylaminoethanol (479 mg), and triphenylphosphine (390 mg) in tetrahydrofuran (3 ml). After stirring at room temperature for 7 hrs, diethylazod icarboxylate (17 mg) and triphenylphosphine (26 mg) was added to the reaction mixture.

Sources & evidence

ORD record
ord-e4b1b4b103d2408ba66da5d754aec11a
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

Loading…