HCID 21090991, compound → 5-[4-(Benzyloxy)phenyl]-1-(4-methoxyphenyl)-1H-pyrazol-3-amine

HRID 351198Notes

Reaction equation

HRID 351198 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[N:19]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[N:18]=[C:17]([NH2:28])[CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CN(C)C=O.O=[Mn]=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[N:18]=[C:17]([NH2:28])[CH:16]=2)=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 21090991HCID 21090991, compound

Product 1

HCID 210909885-[4-(Benzyloxy)phenyl]-1-(4-methoxyphenyl)-1H-pyrazol-3-amine

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalyst2×HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

MnO2 (3.5 g) was added to a solution of 5-[4-(benzyloxy)phenyl]-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-amine obtained by Example 14-1 (12.54 g). in N,N-dimethylformamide (65 ml) and the mixture was stirred at 60° C. for 2 hrs. MnO2 (5.3 g) was added and the mixture was stirred at 60° C. for 1 hr.

Sources & evidence

ORD record
ord-4d591be82b604a20b0783b741d4aedc1
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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