Triethylamine → HCID 21091034, compound

HRID 351211Notes

Reaction equation

HRID 351211 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH2:21])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:22]([F:25])([F:24])[F:23])=[N:9]2)=[CH:4][CH:3]=1.C(N(CC)CC)C.C[Si]([N:37]=[C:38]=[O:39])(C)C>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][C:38]([NH2:37])=[O:39])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:22]([F:23])([F:25])[F:24])=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 70696Trimethylsilyl isocyanateHCID 21090709HCID 21090709, compound

Product 1

HCID 21091034HCID 21091034, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-{4-[l-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl}ethanamine obtained by Example 53 (300 mg) and triethylamine (0.57 ml) in dichloromethane (10 ml) was added dropwise trimethylsilyl isocyanate (0.555 ml) at room temperature.

Sources & evidence

ORD record
ord-379363dc5e1f48b08afa80ebaa8ec9ca
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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