Hydrochloric Acid → HCID 21090872, compound

HRID 351212Notes

Reaction equation

HRID 351212 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)=[CH:12][C:11]([C:22]([F:25])([F:24])[F:23])=[N:10]2)=[CH:5][CH:4]=1.[ClH:26]>CO.[Pd]>[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([C:14]3[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=3)=[CH:12][C:11]([C:22]([F:25])([F:23])[F:24])=[N:10]2)=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21090871HCID 21090871, compound

Product 1

HCID 21090872HCID 21090872, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-[1-(4-methoxyphenyl)-3-(trifluoro-methyl)-1H-pyrazol-5-yl]benzonitrile obtained by Example 56 (430 mg), Pd/C (100 mg) and 1N hydrochloric acid (1.3 ml) in methanol (43 ml) was stirred under Hydrogen atmosphere for 5 hrs.

Sources & evidence

ORD record
ord-a48b3f0be1f148d0a47ab3bd77d046d7
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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