Hydrochloric Acid → HCID 21090728, compound

HRID 351217Notes

Reaction equation

HRID 351217 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]([C:15]3[CH:31]=[CH:30][C:18]([O:19][CH2:20][CH2:21][NH:22]C(=O)OC(C)(C)C)=[CH:17][CH:16]=3)=[CH:13][C:12]([C:32]([F:35])([F:34])[F:33])=[N:11]2)=[CH:6][CH:5]=1>C(OCC)(=O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:14]([C:15]3[CH:31]=[CH:30][C:18]([O:19][CH2:20][CH2:21][NH2:22])=[CH:17][CH:16]=3)=[CH:13][C:12]([C:32]([F:35])([F:33])[F:34])=[N:11]2)=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21091162HCID 21091162, compound

Product 1

HCID 21090728HCID 21090728, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of hydrogen chloride in ethyl acetate (4N, 1.0L) was added powdered tert-Butyl 2-{4-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-phenoxy}ethylcarbamate obtained by Example 73 (500 g) at 5° C. over 20 min.

Workup

  1. customat 5° C.
  2. customover 20 min.

Sources & evidence

ORD record
ord-0d98bbb04f4046a5b30a9f0ba3e4399f
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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