Hydrochloric Acid → HCID 21090819, compound

HRID 351238Notes

Reaction equation

HRID 351238 reaction equation
[ClH:1].[C:2]([C:5]1[CH:9]=[C:8]([C:10]2[CH:26]=[CH:25][C:13]([O:14][CH2:15][CH2:16][NH:17]C(=O)OC(C)(C)C)=[CH:12][CH:11]=2)[N:7]([C:27]2[CH:28]=[N:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=2)[N:6]=1)([CH3:4])=[CH2:3]>O1CCOCC1.C(Cl)Cl>[ClH:1].[ClH:1].[C:2]([C:5]1[CH:9]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][NH2:17])=[CH:25][CH:26]=2)[N:7]([C:27]2[CH:28]=[N:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=2)[N:6]=1)([CH3:4])=[CH2:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69333084HCID 69333084, compound

Product 1

HCID 21090819HCID 21090819, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A 4M solution of HCl in dioxane (2 ml) was added to a solution of ter-butyl (2-{4-[3-isopropenyl-1-(6-methoxy-3-pyridinyl)-1H-pyrazol-5-yl]phenoxy}ethyl)carbamate (269.7 mg) in CH2Cl2 (2 ml) . The reaction mixture was stirred at ambient temperature for 2 hours, then, was concentrated in vacuo to give (2-{4-[3-isopropenyl-1-(6-methoxy-3-pyridinyl)-1H-pyrazol-5-yl]phenoxy}ethyl)amine dihydrochloride (259 mg) as an amorphous powder.

Workup

  1. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-9ee2813136664aa1acb8d14bc75500e9
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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