Hydrochloric Acid → 1-(1-Adamantyl)ethanol

HRID 351325Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 351325
[C:1]([C:4]12[CH2:13][CH:8]3[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]3)[CH2:5]1)[CH2:11]2)(=[O:3])[CH3:2].[OH-].[Na+].[BH4-].[Na+].Cl>O.CO>[CH3:2][CH:1]([C:4]12[CH2:13][CH:8]3[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]3)[CH2:5]1)[CH2:11]2)[OH:3]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 123126Methyl tricyclo(3.3.1.13,7)dec-1-yl ketoneHCID 4311764Sodium borohydride

Produkt 1

HCID 27697131-(1-Adamantyl)ethanolAusbeute 98,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of 45.0 g of 1-acetyladamantane obtained according to the process of Production Example 1, 100 ml of methanol, and 20 ml of a 0.1 N sodium hydroxide aqueous solution on a water bath, 4.8 g of sodium borohydride was gradually added over 30 minutes. The mixture was stirred for further 30 minutes, was neutralized with a 1 N hydrochloric acid aqueous solution, and 200 ml of water was added to the neutralized mixture. The obtained crystal was filtrated, was washed with water, and was dried in vacuo to yield 45.0 g of α-methyl-1-adamantanemethanol.

Aufarbeitung

  1. customobtained
  2. additionwas added to the neutralized mixture
  3. filtrationThe obtained crystal was filtrated
  4. washwas washed with water
  5. customwas dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6c93cc6bd7e145a397498bcef52605ff
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183423B1

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