HRID351384
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
A solution of Example 40 (74.4 mg, 0.120 mmol) in CH3CN (0.9 mL) and 1 M HCl (0.9 mL) was heated at 60° C. for 5 h. The mixture was diluted with ethyl acetate (500 mL), washed with satd NaHCO3 (3×150 mL) and brine (2×100 mL), dried over Na2SO4, filtered, and evaporated to dryness. The residue was lyophilized from CH3CN/H2O to the title compound as a white solid (70.2 mg, >99): ESI MS m/z 579 [C30H37F3N2O4S+H]+.
WORKUP
后处理
- washwashed with satd NaHCO3 (3×150 mL) and brine (2×100 mL)
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated to dryness