反应详情

A mixture of 10.0 g of 4-bromobutyronitrile, 14.7 g of morpholine and 40 g of tetrahydrofuran was heated under reflux for 10 hours. The reaction solution was cooled, diluted with diethyl ether, filtered, and concentrated in vacuum. Purification by vacuum distillation yielded 9.4 g of 4-morpholinobutyronitrile (boiling point: 85° C./50 Pa, yield: 91%).

1. temperaturewas heated
2. temperatureunder reflux for 10 hours
3. temperatureThe reaction solution was cooled
4. filtrationfiltered
5. concentrationconcentrated in vacuum
6. customPurification
7. distillationby vacuum distillation