Hydrogen Bromide → HCID 22713212, compound

HRID 351532Notes

Reaction equation

HRID 351532 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][CH2:14][CH2:15][N:16]3[C:20](=O)[CH2:19]O[CH-]3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(OC(C)C)(C)C.[BrH:29]>C(O)(=O)C>[BrH:29].[BrH:29].[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH2:14][CH2:15][NH:16][CH2:20][CH2:19]3)=[CH:11][CH:12]=2)[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 7914Diisopropyl EtherHCID 131724437HCID 131724437, compound

Product 1

HCID 22713212HCID 22713212, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3-[2-(4-morpholinophenylamino)ethyl]-2-oxazolidone (5 g) in 30% hydrobromic acid in acetic acid (35 ml) was stirred for 24 hours at ambient temperature. The reaction mixture was pulverized with diisopropyl ether. The precipitate was collected by filtration and added to ethanol (35 ml). The solution was refluxed for 8 hours and pulverized with diisopropyl ether. The precipitate was collected by filtration to give 1-(4-morpholinophenyl)-piperazine dihydrobromide (7.42 g).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. additionadded to ethanol (35 ml)
  3. temperatureThe solution was refluxed for 8 hours
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-bb031b7c13af44c0aba45262ccf22caa
Source dataset
uspto-grants-2004_06
Patent number
US06743776B2

Reaction notes

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