Diisopropyl Ether → HCID 22713213, compound

HRID 351554Notes

Reaction equation

HRID 351554 reaction equation
N1(O[C:11](=[O:24])[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:14][CH:13]=2)C2C=CC=CC=2N=N1.[NH2:25][NH:26][C:27]([NH2:29])=[S:28].C(OC(C)C)(C)C>CN(C)C=O>[CH2:19]([O:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]([NH:25][NH:26][C:27]([NH2:29])=[S:28])=[O:24])=[CH:17][CH:16]=1)[CH2:20][CH2:21][CH2:22][CH3:23]

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 2723789ThiosemicarbazideHCID 54044891HCID 54044891, compound

Product 1

HCID 22713213HCID 22713213, compoundYield 115.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-n-pentyloxybenzoic acid benzotriazole-1-yl ester (20 g) in N,N-dimethylformamide (100 ml) was added thiosemicarbazide (6.73 g) and stirred for 7 hours at ambient temperature. The reaction mixture was pulverized with diisopropyl ether. The precipitate was collected by filtration to give 1-(4-n-pentyloxybenzoyl)-3-thiosemicarbazide (20 g).

Workup

  1. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-fa2868a8fab943ec8703b27b15f63901
Source dataset
uspto-grants-2004_06
Patent number
US06743776B2

Reaction notes

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