Water → HCID 1782582, compound

HRID 351560Notes

Reaction equation

HRID 351560 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:22]=[CH:21][C:14]([C:15](OCCC)=[O:16])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)[CH2:2][CH3:3].O.[NH2:24][NH2:25].O>C(O)C.O1CCCC1>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:22]=[CH:21][C:14]([C:15]([NH:24][NH2:25])=[O:16])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)[CH2:2][CH3:3]

Participants

6

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)2×HCID 22713254HCID 22713254, compound

Product 1

HCID 1782582HCID 1782582, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of propyl 4-(4′-propoxyphenyl)benzoate (20.00 g) in a mixture of ethanol (100 ml) and tetrahydrofuran (40 ml) was added hydrazine monohydrate (32.5 ml). The mixture was refluxed for 2 hours, during this period additional hydrazine monohydrate (32.5 ml) was added into the mixture. After cooling to room temperature, the reaction mixture was poured into water (1800 ml) and then the mixture was stirred for 30 minutes at room temperature. The resulting precipitate was filtered, washed with water, and dried to give the objective compound, 4-(4′-propoxyphenyl)-benzoyl hydrazine (17.63 g), as a white solid.

Workup

  1. additionwas added into the mixture
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-575a3ef99d794bbb9f7706d41e8f5abe
Source dataset
uspto-grants-2004_06
Patent number
US06743776B2

Reaction notes

Loading…