Ammonium formate → HCID 59892278, compound

HRID 351631Notes

Reaction equation

HRID 351631 reaction equation
C([O:8][N:9]([CH2:22][C:23]([NH:25][C@H:26]([C:28]1[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=1)[CH3:27])=[O:24])[C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[NH:21])[NH2:20])=[CH:15][CH:14]=1)=[O:11])C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[C:19]([C:16]1[CH:15]=[CH:14][C:13]([NH:12][C:10](=[O:11])[N:9]([CH2:22][C:23]([NH:25][C@H:26]([C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=2)[CH3:27])=[O:24])[OH:8])=[CH:18][CH:17]=1)(=[NH:20])[NH2:21]

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 59892276HCID 59892276, compound

Product 1

HCID 59892278HCID 59892278, compoundYield 63.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The compound of example 46 (104 mg, 0.2 mmol) was hydrogenated by means of ammonium formate (143 mg) and Pd/C (30 mg; 10%) in methanol (10 ml) at room temperature. After 16 h (LC-MS control) the mixture was filtered off and the solvent was removed. Remaining traces of formate were removed in high vacuo at elevated temperature. 47 mg (57%) of the title compound were obtained. MS 370.10 (M+1)+

Workup

  1. filtrationAfter 16 h (LC-MS control) the mixture was filtered off
  2. customthe solvent was removed
  3. customRemaining traces of formate were removed in high vacuo at elevated temperature

Sources & evidence

ORD record
ord-7da3cca408084e55815cfcfa22f4980f
Source dataset
uspto-grants-2004_06
Patent number
US06743790B2

Reaction notes

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