Phenylacetylene → HCID 22714305, compound

HRID 351752Notes

Reaction equation

C([NH:4][C:5]([C:7]1[C:16](=[O:17])[C:15]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[N:9]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20](Br)[CH:19]=2)[CH:8]=1)=[O:6])(C)C.[CH3:25][Si:26]([C:29]#[CH:30])([CH3:28])[CH3:27].C1(C#C)C=CC=CC=1>>[CH3:25][Si:26]([C:29]#[C:30][C:20]1[CH:19]=[C:18]([N:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][N:11]=3)[C:16](=[O:17])[C:7]([C:5]([NH2:4])=[O:6])=[CH:8]2)[CH:23]=[CH:22][CH:21]=1)([CH3:28])[CH3:27]

Participants

Reactant 3

HCID 10821Phenylacetylene

HCID 66111Trimethylsilylacetylene

HCID 129913181-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Product 1

HCID 22714305HCID 22714305, compound

Procedure

Following the procedure of Step 5 of EXAMPLE 1, but substituting the 1-(3-Bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide from present Step 1 for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide and trimethylsilylacetylene for phenylacetylene, the 1-[3-(trimethylsilylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide product was obtained as a solid.

Sources & evidence

ORD record: ord-a9eed907b4114b7fa532b6ca4ea1b9ee
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06743802B2

Reaction notes

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