反应详情

A solution of 14.35 g of tin chloride in 30 ml of concentrated hydrochloric acid is added to a mixture of 5 g of 2-(2-methylpyrid-3-yloxy)-5-nitropyridine and the whole is heated at reflux for 1 hour. The reaction mixture is cooled and adjusted to basic pH by the addition of concentrated sodium hydroxide solution. After the removal of a precipitate by filtration, the aqueous phase is extracted with ethyl acetate. After conventional working up, the expected product is isolated in the form of a violet powder.

1. temperaturethe whole is heated
2. temperatureat reflux for 1 hour
3. temperatureThe reaction mixture is cooled
4. customAfter the removal of a precipitate
5. filtrationby filtration
6. extractionthe aqueous phase is extracted with ethyl acetate