2-Chloro-3-nitropyridine → HCID 22714503, compound

HRID 351938Notes

Reaction equation

HRID 351938 reaction equation
Cl.[C:2]1([CH:8]([C:15]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH2:25][CH2:26][CH2:27][NH2:28])=[CH:21][CH:22]=3)[NH:17][CH:16]=2)[CH2:9][C:10]([O:12]CC)=[O:11])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:30]1[C:35]([N+:36]([O-:38])=[O:37])=[CH:34][CH:33]=[CH:32][N:31]=1>C(N(CC)CC)C>[N+:36]([C:35]1[C:30]([NH:28][CH2:27][CH2:26][CH2:25][O:24][C:20]2[CH:19]=[C:18]3[C:23]([C:15]([CH:8]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH2:9][C:10]([OH:12])=[O:11])=[CH:16][NH:17]3)=[CH:22][CH:21]=2)=[N:31][CH:32]=[CH:33][CH:34]=1)([O-:38])=[O:37]

Participants

4

Reactant 2

HCID 796132-Chloro-3-nitropyridineHCID 22714435HCID 22714435, compound

Product 1

HCID 22714503HCID 22714503, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Analogously to Example 18, the compound 35, prepared in accordance with Example 14.2, is reacted with 2-chloro-3-nitropyridine and triethylamine, giving 3-{6-[3-(3-nitropyridin-2-ylamino)propoxy]-1H-indol-3-yl}-3-phenylpropionic acid. After preparative HPLC: 3-{6-[3-(3-nitropyridin-2-yl-amino)propoxy]-1H-indol-3-yl}-3-phenylpropionic acid trifluoroacetate.

Sources & evidence

ORD record
ord-504f0b48df1341609e4bf06d314c3936
Source dataset
uspto-grants-2004_06
Patent number
US06743810B2

Reaction notes

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