Methanesulfonic Acid → HCID 86587405, compound

HRID 351940Notes

Reaction equation

HRID 351940 reaction equation
[C:1]1([C@@H:7]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([O:21][CH2:22][CH2:23][CH2:24][NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:32][S:33]([OH:36])(=[O:35])=[O:34]>O1CCOCC1.O>[CH3:32][S:33]([OH:36])(=[O:35])=[O:34].[C:1]1([C@@H:7]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([O:21][CH2:22][CH2:23][CH2:24][NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11486828HCID 11486828, compound

Product 1

HCID 86587405HCID 86587405, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

2 g (4.8 mmol) of the internal salt 46 are dissolved in 5 ml of dioxane and stirred for 2 hours at RT with 310 μl (4.8 mmol) of methanesulfonic acid in 5 ml of water. The solution is subsequently evaporated, giving (3S)-3-phenyl-3-{6-[3-(pyridin-2-ylamino)propoxy]indol-3-yl}propionic acid methanesulfonate after freeze-drying from acetonitrile/water.

Workup

  1. customThe solution is subsequently evaporated

Sources & evidence

ORD record
ord-6a9001ec1d0148c58ffe7199be494a92
Source dataset
uspto-grants-2004_06
Patent number
US06743810B2

Reaction notes

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