Triphenylphosphine → HCID 22714969, compound

To a flame dried flask was added PPh3 (1.76 g, 6.73 mmol) followed by dry CH2Cl2 (60 mL). The mixture was placed in an ice bath and bromine (0.34 mL, 6.41 mmol) was added dropwise. A small amount of PPh3 was added until the reaction went from yellow to clear in color. After 0.5 h at 0° C., 5-trimethylsilanylpent-2-yn-1-ol (1.0 g, 6.41 mmol) was dissolved in CH2Cl2 (5 mL) and added dropwise. After 4 h at 0i C, the reaction mixture was poured into a separatory funnel, diluted with pentane (250 mL) and extracted with H2O (100 mL) and sat. NaHCO3 (100 mL). The organic layer was dried (MgSO4), filtered and reduced in volume to 50 mL. The crude solution was chromatographed on a pad of silica gel with pentane (500 mL). After evaporation of the pentane, (5-bromopent-3-ynyl)trimethylsilane (1.2 g 87%) was obtained as a clear oil: IR (neat, cm−1) 2953, 2922, 2899, 2230, 1431, 1317, 1248, 1208, 852; 1H NMR (300 MHz, CDCl3) δ0.03 (s, 9 H), 0.79 (t, J=8 Hz, 2 H), 2.28 (tt, J1=8 Hz, J2=2 Hz, 2 H), 3.92 (t, J=2 Hz, 2 H); 13C NMR (75 MHz, CDCl3) δ1.7, 13.6, 15.7, 15.8, 74.6, 90.2; HRMS (EI) m/z calcd for C7H12BrSi (M-CH3) 202.9892, found 202.9889 LRMS (EI) m/z 203 (M-CH3), 137, 73, 66.

1. customTo a flame dried flask
2. customThe mixture was placed in an ice bath
3. additionadded dropwise
4. additionthe reaction mixture was poured into a separatory funnel
5. extractionextracted with H2O (100 mL) and sat. NaHCO3 (100 mL)
6. dry with materialThe organic layer was dried (MgSO4)
7. filtrationfiltered
8. customThe crude solution was chromatographed on a pad of silica gel with pentane (500 mL)
9. customAfter evaporation of the pentane

ORD record

ord-00b4a0644d88485d850409048908165b

Source dataset

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06743917B2