反应详情

2-Chloro-N-(2-methylpropyl)-6-methyl-3-nitropyridin-4-amine (5.00 g) from Part A, toluene (100 ml), and 5% platinum on carbon (3.5 g) were added to a Parr shaker and placed on a hydrogenator at a hydrogen pressure of 345 kPa for 4 hours. The reaction, monitored by HPLC, was complete, and the resulting reaction mixture was filtered through a fluted filter paper and then through a folded No.2 Whatman filter. The solvent was removed from the filtrate under reduced pressure, and the resulting oil (4.14 g) was carried on to the next step.

1. customThe reaction
2. customthe resulting reaction mixture
3. filtrationwas filtered through
4. filtrationa fluted filter paper
5. filtrationthrough a folded No.2 Whatman filter
6. customThe solvent was removed from the filtrate under reduced pressure