反应详情

温度

80 °C

Trifluoromethanesulfonic acid (4 ml) was ice-cooled, and 4-aminobutyric acid (1093 mg, 10.6 mmol) was added. Then, anisole (1 ml, 9.25 mmol) was added. The mixture was heated and stirred at 80° C. for 50 min. The mixture was cooled to room temperature and added dropwise to water (17 ml) under ice-cooling. The mixture was stirred under ice-cooling for 20 min and then at −10° C. for 30 min. The crystals were filtrated, washed with ice-cooled saturated brine, and dried under reduced pressure to give 4-amino-4′-methoxybutyrophenone trifluoromethanesulfonate (2.47 g, yield 78%).

1. temperaturecooled
2. temperatureThe mixture was heated
3. temperatureThe mixture was cooled to room temperature
4. temperaturecooling
5. stirringThe mixture was stirred under ice-
6. temperaturecooling for 20 min
7. waitat −10° C. for 30 min
8. filtrationThe crystals were filtrated
9. washwashed with ice-
10. temperaturecooled saturated brine
11. customdried under reduced pressure