反应详情

A solution of the product from Example 1 step (c) (200 mg) and 2-(ethylamino)ethanol (163 mg, 0.14 ml) in tetrahydrofuran (5 ml) was stirred for 2 days. The solvent was removed in vacuo and the residue dissolved in water and aqueous potassium carbonate and extracted with ethyl acetate (three times). The combined organic extracts were washed with water, dried (Na2SO4) and evaporated to give an oil. To a solution of this amine in diethyl ether-dichloromethane was added a 1M solution of hydrogen chloride in diethyl ether. The crystals that formed were collected and dried to afford the title compound as a white solid (65 mg). M.p. 141-144° C.

1. customThe solvent was removed in vacuo
2. dissolutionthe residue dissolved in water
3. extractionaqueous potassium carbonate and extracted with ethyl acetate (three times)
4. washThe combined organic extracts were washed with water
5. dry with materialdried (Na2SO4)
6. customevaporated
7. customto give an oil
8. customThe crystals that formed
9. customwere collected
10. customdried