3-Furaldehyde → 1-(3-Furanyl)-1,4-butanediol

HRID 352127Notes

Reaction equation

HRID 352127 reaction equation
S1[CH:5]=[CH:4][C:3]([CH:6]([OH:11])[CH2:7][CH2:8][CH2:9][OH:10])=[CH:2]1.[O:12]1C=CC(C=O)=C1>O1CCCC1>[O:12]1[CH:5]=[CH:4][C:3]([CH:6]([OH:11])[CH2:7][CH2:8][CH2:9][OH:10])=[CH:2]1

Participants

4

Reactant 2

HCID 103513-FuraldehydeHCID 227150901-(3-Thienyl)-1,4-butanediol

Product 1

HCID 135212421-(3-Furanyl)-1,4-butanediol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The Grignard reagent prepared in Example 26 step (a) (0.7M, 28 ml, 19.6 mmol) and furan-3-carboxaldehyde (1.92 g, 20 mmol) in anhydrous tetrahydrofuran (15 ml) were used to prepare the title compound, using the procedure described in Example 26 step (a). The product was a colourless oil (2.42 g, 79%).

Sources & evidence

ORD record
ord-67b58915a98543c68995a3e7b8e48989
Source dataset
uspto-grants-2004_06
Patent number
US06743939B2

Reaction notes

Loading…