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HRID35219

反应详情

EQUATION

反应方程式

HRID 35219 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)Cl
HCID6367

Acetyl chloride

C2H3ClO

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc([N+](=O)[O-])cc4[nH]cc(c34)C[C@H]2N(C)C1
HCID13374957

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc([N+](=O)[O-])cc4c3c(cn4C(C)=O)C[C@H]2N(C)C1
HCID86742359

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)([O-])O
催化剂HCID94433

未命名化合物

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

结构：O=C([O-])O.[Na+]
溶剂HCID516892

Sodium Bicarbonate

CHNaO3

PROCEDURE

实验过程

A solution is prepared from 410 mg of 3-(13-nitro-6-methyl-8α-ergolinyl)-1,1-diethylurea in 10 ml of methylene chloride, 40 mg of tetrabutylammonium hydrogen sulfate and 0.8 ml of acetyl chloride are added, and this mixture is poured on 1 g of pulverized potassium hydroxide. After 1.5 hours of agitation at room temperature, the mixture is diluted with sodium bicarbonate solution, the organic phase is separated and dried with sodium sulfate. After evaporation and chromatography as indicated in Example 9, 375 mg of 3-(1-acetyl-6-methyl-13-nitro-8α-ergolinyl)-1,1-diethylurea is obtained.

WORKUP

后处理

  1. additionare added
  2. customthe organic phase is separated
  3. dry with materialdried with sodium sulfate
  4. customAfter evaporation and chromatography