Trifluoroacetic acid → HCID 19900649, compound

HRID 352334Notes

Reaction equation

HRID 352334 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:12]1[CH:13]=[C:14]([CH:24]=[C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:26]=1[OH:27])[O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])([CH3:11])([CH3:10])[CH3:9]>ClCCl>[C:8]([C:12]1[CH:13]=[C:14]([CH:24]=[C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:26]=1[OH:27])[O:15][CH2:16][C:17]([OH:19])=[O:18])([CH3:11])([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22711584HCID 22711584, compound

Product 1

HCID 19900649HCID 19900649, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.6 ml (46 mmol) of trifluoroacetic acid is added to a solution of 1.56 g (4.64 mmol) of tert-butyl 2-[3,5-di(tert-butyl)-4-hydroxyphenoxy]acetate (prepared according to J. Heterocycl. Chem. (1994) 31, 1439-1443) in 20 ml of dichloromethane. The reaction mixture is stirred for 1 hour, concentrated under vacuum and the residue is dissolved in

Workup

  1. concentrationconcentrated under vacuum
  2. dissolutionthe residue is dissolved in

Sources & evidence

ORD record
ord-b9d38a97da48402ca6da0467bdb1c0b3
Source dataset
uspto-grants-2004_06
Patent number
US06747024B1

Reaction notes

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