Isopropylamine → HCID 178426032, compound

HRID 352535Notes

Reaction equation

HRID 352535 reaction equation
[F:1][C:2]([C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:26](=[O:27])[C:25]3[C:20](=[N+:21]([O-:28])[CH:22]=[CH:23][CH:24]=3)C2=O)=[C:13]([CH3:29])[CH:12]=1)([C:7]([F:10])([F:9])[F:8])[C:3]([F:6])([F:5])[F:4].[CH:30]([NH2:33])([CH3:32])[CH3:31].C1C[O:37][CH2:36]C1>>[F:1][C:2]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:26]([CH:25]2[C:24](=[C:36]=[O:37])[CH:23]=[CH:22][N+:21]([O-:28])=[C:20]2[NH:33][CH:30]([CH3:32])[CH3:31])=[O:27])=[C:13]([CH3:29])[CH:12]=1)([C:3]([F:4])([F:5])[F:6])[C:7]([F:10])([F:8])[F:9]

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 8028TetrahydrofuranHCID 22712039HCID 22712039, compound

Product 1

HCID 178426032HCID 178426032, compoundYield 63%

Procedure

In 10 ml of THF was dissolved 400 mg of N-[4-(heptafluoro-2-propyl)-2-methylphenyl]pyridine-2,3-dicarboximide-1-oxide, followed by adding thereto 200 mg of isopropylamine, and the resulting mixture was stirred at room temperature for 5 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the resulting residue was purified by a silica gel column chromatography using ethyl acetate/n-hexane as an eluent, to obtain 290 mg of the desired compound as white crystals.

Workup

  1. additionby adding
  2. customAfter completion of the reaction
  3. distillationthe solvent was distilled off under reduced pressure
  4. customthe resulting residue was purified by a silica gel column chromatography

Sources & evidence

ORD record
ord-c233c3cfe1294d8da8b4e698a47fcef3
Source dataset
uspto-grants-2004_06
Patent number
US06747041B1

Reaction notes

Loading…