反应详情

At room temperature, methyl 4-(2-aminothiazol-4-yl)benzoate (300 mg) was suspended in a mixed solvent of tetrahydrofuran (5 ml) and methanol (5 ml), followed by the addition of a 1N aqueous sodium hydroxide solution (10 ml). The resulting mixture was stirred for one hour. To the reaction mixture, N,N-dimethylformamide (5 ml) was added, followed by heating under reflux for 6 hours. After completion of the reaction, the solvent was distilled off. To the residue, water and 1N hydrochloric acid were added successively and the pale yellow solid so precipitated was collected by filtration, whereby the title compound (229 mg, 69%) was obtained as a pale yellow solid.

1. customAt room temperature
2. temperatureby heating
3. temperatureunder reflux for 6 hours
4. customAfter completion of the reaction
5. distillationthe solvent was distilled off
6. additionTo the residue, water and 1N hydrochloric acid were added successively
7. customthe pale yellow solid so precipitated
8. filtrationwas collected by filtration, whereby the title compound (229 mg, 69%)
9. customwas obtained as a pale yellow solid