Hydrochloric Acid → 2-Ethyl piperazine hydrochloride

HRID 352798Notes

Reaction equation

HRID 352798 reaction equation
[ClH:1].C([N:9]1[CH2:14][CH2:13][N:12](CC2C=CC=CC=2)[CH2:11][CH:10]1[CH:22]=[CH2:23])C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[ClH:1].[CH2:22]([CH:10]1[CH2:11][NH:12][CH2:13][CH2:14][NH:9]1)[CH3:23]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 111621581,4-Dibenzyl-2-ethenylpiperazine

Product 1

HCID 227107862-Ethyl piperazine hydrochloride

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

At room temperature, concentrated hydrochloric acid (6 ml) and palladium hydroxide (1.1 g) were added to solution (600 ml) of 1,4-dibenzyl-2-ethenylpiperazine (10.9 g)in ethanol, followed by stirring for 12 hours under a hydrogen gas stream of 1 atmospheric pressure. The catalyst was filtered off and the solvent was distilled off under reduced pressure. The resulting residue was solidified using methylene chloride—diethyl ether, followed by washing with diethyl ether. The resulting solid was dried under reduced pressure, whereby the title compound (6.516 g) was obtained as a brown solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off under reduced pressure
  3. washby washing with diethyl ether
  4. dry with materialThe resulting solid was dried under reduced pressure, whereby the title compound (6.516 g)
  5. customwas obtained as a brown solid

Sources & evidence

ORD record
ord-76c90d2979024a5e9b56c257aedb4e24
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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