反应详情

In dichloromethane (15 ml), methyl 5-benzimidazolecarboxylate hydrochloride (1.00 g) was suspended. To the resulting suspension, triethylamine (1.50 ml) and triphenylmethyl chloride (1.50 g) were added, followed by stirring at room temperature for 3 hours. The reaction mixture was diluted with dichloromethane, washed with water, and dried over anhydrous sodium sulfate. The residue obtained by distilling off the solvent under reduced pressure was purified by chromatography on a silica gel column (hexane:ethyl acetate=2:1), whereby title compound (2.10 g, quant.) was obtained as a yellow solid.

1. washwashed with water
2. dry with materialdried over anhydrous sodium sulfate
3. customThe residue obtained
4. distillationby distilling off the solvent under reduced pressure
5. customwas purified by chromatography on a silica gel column (hexane:ethyl acetate=2:1)